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No projectiles/beams of light will be used (just like when ? (boss) is reduced to 0 hp). If Isaac is on 0 hp, the wings and light will disappear, and Isaac will resume crying on the floor. It is possible to reduce Isaac to 0 health.However, any Angelic Babies in the fight can take a small amount of damage from his light beams. Isaac cannot be damaged by the Crack The Sky light beams, or by his own.Activating Mom's Bra or triggering the special effect of Mom's Contacts will prevent Isaac from spawning enemies or attacking at all-including when damaged-for the duration of the effect.Applying slow effects such as Little Gish or Spider Bite to Isaac will not affect the speed of his homing tears, but will slow all normal tears.This also applies to effects which apply damage rapidly, such as Mom's Knife.
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Using items with a high fire rate (such as Technology 2) is dangerous in this fight, as Isaac will retaliate with a very large amount of tears upon being hit, unless the player have Mom's Contacts.Using The Bible during or after the fight will instantly kill the player (Similar to ? and Satan) unless they have The Wafer item, which will deal 1/2 heart damage instead.
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